Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.46 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30445752 | 1.00 | MKNK1 (0.46) | MKNK1MKNK2EIF4EADORA2AJAK2 | |
| SCHEMBL24086888 | 0.93 | ADORA2A (0.48) | MKNK1MKNK2EIF4EADORA2AJAK2 | |
| SCHEMBL24086868 | 0.90 | ADORA2A (0.52) | MKNK1MKNK2EIF4EADORA2AMETAP2 | |
| SCHEMBL24087042 | 0.88 | ADORA2A (0.45) | MKNK1MKNK2EIF4EADORA2A | |
| SCHEMBL30445664 | 0.86 | ADORA2A (0.42) | MKNK1MKNK2EIF4EADORA2AMETAP2 | |
| SCHEMBL25334728 | 0.85 | ADORA2A (0.42) | MKNK1MKNK2EIF4EADORA2AJAK2 | |
| SCHEMBL25338820 | 0.81 | ADORA2A (0.50) | MKNK1MKNK2ADORA2A | |
| SCHEMBL24087072 | 0.81 | ADORA2A (0.60) | MKNK1MKNK2ADORA2A | |
| SCHEMBL24086965 | 0.81 | ADORA2A (0.48) | MKNK1MKNK2EIF4EADORA2ACYP3A4 | |
| SCHEMBL24087048 | 0.81 | ADORA2A (0.48) | MKNK1MKNK2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3870582-B1 | 5-AZAINDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2023-07-19 | — | — | EP | claimed |