Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 2/20 | 0.46 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27211356 | 1.00 | PIK3CD (0.51) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL30473674 | 1.00 | PIK3CD (0.51) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL27211334 | 0.88 | PDE4B (0.47) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL29457556 | 0.88 | PDE4B (0.47) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL27211151 | 0.88 | PDE4B (0.47) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL25343640 | 0.88 | PDE4B (0.47) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL25343649 | 0.88 | PDE4B (0.47) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL25342400 | 0.88 | PDE4B (0.47) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL27211190 | 0.88 | PDE4B (0.47) | PIK3CDPRMT5PIK3CAPDE4BHPGDS | |
| SCHEMBL30473704 | 0.87 | PRMT5 (0.46) | PIK3CDPRMT5PIK3CAPDE4BHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225746-A1 | MRGX2 ANTAGONISTS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022073904-A1 | MRGX2 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2022-04-14 | — | — | WO | disclosed |