Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 8/20 | 0.45 |
| ▸ | SLC2A3 | P11169 | 8/20 | 0.45 |
| ▸ | SLC2A2 | P11168 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25344048 | 0.85 | TP53 (0.42) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL25344741 | 0.85 | SLC2A1 (0.56) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL25342411 | 0.81 | HTT (0.54) | TP53LMNAPOLBCYP17A1CYP1A2 | |
| SCHEMBL25343109 | 0.81 | SLC2A1 (0.45) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL30568414 | 0.80 | CYP17A1 (0.53) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL839701 | 0.80 | CYP17A1 (0.53) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL839044 | 0.80 | CYP17A1 (0.55) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL25343909 | 0.78 | CYP17A1 (0.42) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL25343463 | 0.78 | TP53 (0.44) | SLC2A1SLC2A3SLC2A2TP53LMNA | |
| SCHEMBL838540 | 0.78 | TP53 (0.57) | SLC2A1SLC2A3SLC2A2TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |