Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369115 | 1.00 | TDP1 (0.45) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL12256803 | 1.00 | TDP1 (0.45) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2369118 | 1.00 | TDP1 (0.45) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL12256889 | 0.90 | TDP1 (0.44) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2369473 | 0.90 | TDP1 (0.41) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2369066 | 0.90 | TDP1 (0.41) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2369073 | 0.90 | TDP1 (0.41) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2369063 | 0.90 | TDP1 (0.41) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2369476 | 0.90 | TDP1 (0.41) | TDP1ATMFFAR1FFAR4ALDH1A1 | |
| SCHEMBL2369459 | 0.89 | TDP1 (0.45) | TDP1ATMALDH1A1MAPTHSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |