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SCHEMBL25347462

SCHEMBL25347462

Cc1cnc2c(C(=O)Nc3cncc(C4(c5nncn5C)CC(C)C4)c3)cc(CNC3CC(C)C3)cn12

nearest known ligand 0.41

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 15/20 0.41
▸ CBLC Q9ULV8 1/20 0.37
▸ PDCD1 Q15116 1/20 0.34
▸ CD274 Q9NZQ7 1/20 0.34
▸ CBL P22681 7/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31578208 1.00 CBLB (0.41) CBLBCBLCPDCD1CD274CBL
SCHEMBL25348995 0.89 CBLB (0.41) CBLBCBLCCBL
SCHEMBL31578206 0.88 CBLB (0.42) CBLBCBLCPDCD1CD274CBL
SCHEMBL31578188 0.88 CBLB (0.41) CBLBCBLCPDCD1CD274CBL
SCHEMBL25347420 0.88 CBLB (0.43) CBLBCBLCCBL
SCHEMBL31578136 0.88 CBLB (0.43) CBLBCBLCPDCD1CD274CBL
SCHEMBL31578195 0.88 CBLB (0.43) CBLBCBLCCBL
SCHEMBL31115418 0.84 CBLB (0.44) CBLBCBLCCBL
SCHEMBL31578225 0.82 CBLB (0.45) CBLBCBLCPDCD1CD274CBL
SCHEMBL25346985 0.81 CBLB (0.39) CBLBCBLCCBL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023151636-A1 HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH BEIGENE , LTD. (KY) 2023-08-17 — — WO disclosed
WO-2023151640-A1 HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH BEIGENE , LTD. (KY) 2023-08-17 — — WO disclosed
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