Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.53 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2532587 | 0.90 | PSEN1 (0.52) | PSEN1ALOX5PPARGPTGESPPARD | |
| SCHEMBL2534584 | 0.83 | ERN1 (0.50) | PSEN1ALOX5PPARDSERPINE1MRGPRX4 | |
| SCHEMBL2532595 | 0.83 | PTGER4 (0.55) | PSEN1ALOX5PPARGPPARDSERPINE1 | |
| SCHEMBL2532594 | 0.83 | PTGER4 (0.55) | PSEN1ALOX5PPARGPPARDSERPINE1 | |
| SCHEMBL2537060 | 0.83 | PTGER4 (0.55) | PSEN1ALOX5PPARGPPARDSERPINE1 | |
| SCHEMBL2534034 | 0.82 | HDAC8 (0.51) | PSEN1ALOX5PPARDMRGPRX4PTGER4 | |
| SCHEMBL2539621 | 0.80 | KDM4E (0.49) | PSEN1ALOX5PPARDMRGPRX4ERN1 | |
| SCHEMBL2536635 | 0.80 | PTGER4 (0.51) | PSEN1ALOX5PPARGPPARDMRGPRX4 | |
| SCHEMBL2532399 | 0.80 | PTGER4 (0.51) | PSEN1ALOX5PPARGPPARDMRGPRX4 | |
| SCHEMBL2536639 | 0.80 | PTGER4 (0.51) | PSEN1ALOX5PPARGPPARDMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044236-B2 | Inhibitors against plasminogen activator inhibitor-1 (PAI-1); anticoagulants; 2-(aryl or aralkyloxy-)-5-(aryl)phenyl}acetic acid (or derivatives of propionic acid, propenoic acid, N-oxamic acid or 1H-tetrazol-5-yl); occlusion, stenosis; low molecular weight; gene expression inhibition | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2011-10-25 | — | — | US | disclosed |