Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 16/20 | 0.82 |
| ▸ | SMARCA2 | P51531 | 15/20 | 0.82 |
| ▸ | SMARCA4 | P51532 | 15/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 10/20 | 0.82 |
| ▸ | BRD4 | O60885 | 1/20 | 0.82 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18038695 | 0.90 | PBRM1 (1.00) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL22777213 | 0.84 | PBRM1 (0.71) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL22802813 | 0.81 | PBRM1 (0.72) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL18080925 | 0.81 | SMARCA2 (0.66) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL22794168 | 0.80 | PBRM1 (0.64) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL25348542 | 0.79 | SMARCA2 (0.70) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL3794902 | 0.78 | HSD17B10 (0.65) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL31380575 | 0.78 | PBRM1 (0.67) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL21421687 | 0.78 | PBRM1 (0.67) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL21455999 | 0.78 | SMARCA2 (0.74) | PBRM1SMARCA2SMARCA4NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025094065-A1 | AMINO-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | AURIGENE ONCOLOGY LIMITED (IN) | 2025-05-08 | — | — | WO | disclosed |
| US-20250145609-A1 | 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | AURIGENE ONCOLOGY LIMITED (IN) | 2025-05-08 | — | — | US | disclosed |
| EP-4476225-A1 | 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | Aurigene Oncology Limited (IN) | 2024-12-18 | — | — | EP | disclosed |
| CN-118871440-A | 3-Substituted pyridazine compounds as SMARCA2 and/or SMARCA4 degrading agents | 奥瑞基尼肿瘤有限公司 | 2024-10-29 | — | — | CN | disclosed |
| WO-2023152666-A1 | 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250145609-A1 | 3-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | SMARCC1, SMARCC2, SMARCA4 | PBRM1 18/4885SMARCA2 4/4885SMARCA4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.