Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.70 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.40 |
| ▸ | PTAFR | P25105 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2693482 | 0.84 | SLC6A2 (0.72) | SLC6A2SLC6A4SLC6A3CYP2A6PTAFR | |
| SCHEMBL9372437 | 0.82 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3CYP2A6PTAFR | |
| SCHEMBL2689197 | 0.82 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2A6CYP3A4 | |
| SCHEMBL7536965 | 0.81 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3CYP2A6CYP3A4 | |
| SCHEMBL2690541 | 0.79 | SLC6A4 (0.76) | SLC6A2SLC6A4SLC6A3CYP2A6PTAFR | |
| SCHEMBL9161142 | 0.79 | CYP2A6 (0.47) | SLC6A2SLC6A4SLC6A3CYP2A6PTAFR | |
| SCHEMBL5536034 | 0.78 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3CYP2A6PTAFR | |
| SCHEMBL12903063 | 0.77 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3CYP2A6PTAFR | |
| SCHEMBL2745656 | 0.72 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25356284 | 0.72 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3PTAFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |