⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696049 | 0.59 | — | — | |
| SCHEMBL12841560 | 0.56 | — | — | |
| SCHEMBL320324 | 0.54 | — | — | |
| SCHEMBL13335242 | 0.53 | — | — | |
| SCHEMBL1218301 | 0.52 | — | — | |
| SCHEMBL11106991 | 0.51 | — | — | |
| SCHEMBL5504503 | 0.51 | — | — | |
| SCHEMBL14489238 | 0.51 | — | — | |
| SCHEMBL22265038 | 0.49 | — | — | |
| SCHEMBL18649660 | 0.48 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937673-B1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI SA (FR) | 2015-10-21 | — | — | EP | disclosed |
| US-8044208-B2 | inhibit the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor); 3-(6-aminopyridin-3-yl)-2-{1-[5-(5-chlorothiophen-2-yl)isoxazol-3-ylmethyl]-1H-imidazol-4-yl}propionic acid | SANOFI-AVENTIS (FR) | 2011-10-25 | — | — | US | disclosed |
| US-20080262028-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI-AVENTIS (FR) | 2008-10-23 | — | — | US | disclosed |
| EP-1937673-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007045339-A1 | IMIDAZOLE DERIVATIVES AS INHIBITORS OF TAFIA | SANOFI-AVENTIS (DE) | 2007-04-26 | — | — | WO | disclosed |