Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.83 |
| ▸ | AKT2 | P31751 | 9/20 | 0.83 |
| ▸ | AKT3 | Q9Y243 | 9/20 | 0.83 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26042806 | 1.00 | AKT1 (0.83) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30784105 | 1.00 | AKT1 (0.83) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL26124939 | 1.00 | AKT1 (0.83) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30784153 | 1.00 | AKT1 (0.83) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL25358847 | 0.92 | AKT1 (0.71) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30784555 | 0.92 | AKT1 (0.76) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30784080 | 0.92 | AKT1 (0.76) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30783759 | 0.92 | AKT1 (0.76) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30783640 | 0.91 | AKT1 (0.80) | AKT1AKT2AKT3PIK3CAPIK3CB | |
| SCHEMBL30784171 | 0.91 | AKT1 (0.80) | AKT1AKT2AKT3PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | claimed |
| WO-2024026424-A1 | QUINAZOLINONE DERIVATIVES AS AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |