Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 17/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25359498 | 1.00 | OPRL1 (0.43) | OPRL1 | |
| SCHEMBL31387368 | 0.86 | OPRL1 (0.39) | OPRL1 | |
| SCHEMBL26064325 | 0.86 | OPRL1 (0.39) | OPRL1 | |
| SCHEMBL25357188 | 0.86 | OPRL1 (0.35) | OPRL1 | |
| SCHEMBL1810594 | 0.82 | OPRL1 (0.49) | OPRL1 | |
| SCHEMBL25358357 | 0.80 | — | — | |
| SCHEMBL25356900 | 0.80 | OPRL1 (0.46) | OPRL1 | |
| SCHEMBL25359152 | 0.80 | OPRL1 (0.46) | OPRL1 | |
| SCHEMBL25359821 | 0.79 | — | — | |
| SCHEMBL25358396 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |