Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 10/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.51 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL253408 | 0.83 | SCN5A (0.75) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL252906 | 0.67 | SCN5A (0.68) | SCN5ASCN1ASCN2A | |
| SCHEMBL252058 | 0.67 | SCN5A (1.00) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL252872 | 0.67 | SCN5A (0.64) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL937200 | 0.66 | SCN5A (0.76) | SCN5ASCN1ASCN2A | |
| SCHEMBL253370 | 0.65 | SCN5A (0.65) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL937775 | 0.65 | SCN5A (0.66) | SCN5ASCN1ASCN2A | |
| SCHEMBL248577 | 0.64 | SCN5A (0.81) | SCN5ASCN1ASCN2AGPR139 | |
| SCHEMBL938543 | 0.63 | SCN5A (0.59) | SCN5ASCN1ASCN2AGRM2 | |
| SCHEMBL12889521 | 0.62 | PDE2A (0.45) | SCN5AGRM2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588197-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003392-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |