Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.81 |
| ▸ | MET | P08581 | 2/20 | 0.77 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.66 |
| ▸ | INSR | P06213 | 6/20 | 0.64 |
| ▸ | IGF1R | P08069 | 6/20 | 0.64 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | STK25 | O00506 | 1/20 | 0.59 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | CASK | O14936 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | MUSK | O15146 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26496845 | 0.97 | EGFR (0.81) | EGFRMETALKINSRIGF1R | |
| SCHEMBL30497499 | 0.97 | EGFR (0.81) | EGFRMETALKINSRIGF1R | |
| SCHEMBL26495301 | 0.94 | ALK (0.74) | EGFRMETALKZAP70 | |
| SCHEMBL30497488 | 0.94 | ALK (0.74) | EGFRMETALKZAP70 | |
| SCHEMBL25874807 | 0.94 | EGFR (0.72) | EGFRMETALKINSRIGF1R | |
| SCHEMBL25874095 | 0.91 | EGFR (0.72) | EGFRMETALKINSRIGF1R | |
| SCHEMBL29021189 | 0.91 | EGFR (0.77) | EGFRMETALKINSRIGF1R | |
| SCHEMBL30936814 | 0.91 | EGFR (0.74) | EGFRMETALKINSRIGF1R | |
| SCHEMBL30497500 | 0.90 | EGFR (0.65) | EGFRMETALKZAP70 | |
| SCHEMBL26500041 | 0.90 | EGFR (0.65) | EGFRMETALKZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265116-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEONE MEDICINES I GMBH (CH) | 2023-08-24 | — | — | US | disclosed |
| US-20230265116-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEONE MEDICINES I GMBH (CH) | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265116-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | EGFR, CBL, ERBB2 | EGFR 1/4885MET 63/4885ALK 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.