Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.80 |
| ▸ | JAK2 | O60674 | 12/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25370238 | 1.00 | JAK1 (0.80) | JAK1JAK2 | |
| SCHEMBL25368736 | 0.92 | JAK1 (0.79) | JAK1JAK2 | |
| SCHEMBL25368733 | 0.92 | JAK1 (0.79) | JAK1JAK2 | |
| SCHEMBL25371490 | 0.92 | JAK1 (0.80) | JAK1JAK2 | |
| SCHEMBL25371486 | 0.92 | JAK1 (0.80) | JAK1JAK2 | |
| SCHEMBL25410426 | 0.89 | JAK1 (1.00) | JAK1JAK2 | |
| SCHEMBL18662677 | 0.89 | JAK1 (1.00) | JAK1JAK2 | |
| SCHEMBL29392629 | 0.89 | JAK1 (1.00) | JAK1JAK2 | |
| SCHEMBL25410279 | 0.88 | JAK1 (1.00) | JAK1JAK2 | |
| SCHEMBL18662691 | 0.88 | JAK1 (1.00) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353168-B1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | DIZAL JIANGSU PHARMACEUTICAL CO LTD (CN) | 2023-08-30 | — | — | EP | disclosed |
| EP-4219482-A1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-08-02 | — | — | EP | disclosed |