Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.59 |
| ▸ | SCN8A | Q9UQD0 | 9/20 | 0.57 |
| ▸ | SCN10A | Q9Y5Y9 | 8/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30530122 | 1.00 | LRRK2 (0.59) | LRRK2SCN8ASCN10ARXFP1 | |
| SCHEMBL25372330 | 0.94 | SCN8A (0.64) | LRRK2SCN8ASCN10ARXFP1 | |
| SCHEMBL30530159 | 0.94 | SCN8A (0.64) | LRRK2SCN8ASCN10ARXFP1 | |
| SCHEMBL25374778 | 0.88 | SCN8A (0.67) | LRRK2SCN8ASCN10A | |
| SCHEMBL30530109 | 0.88 | SCN8A (0.67) | LRRK2SCN8ASCN10A | |
| SCHEMBL25374322 | 0.83 | SCN10A (0.66) | LRRK2SCN8ASCN10A | |
| SCHEMBL30530055 | 0.83 | SCN10A (0.66) | LRRK2SCN8ASCN10A | |
| SCHEMBL30530154 | 0.83 | SCN8A (0.66) | LRRK2SCN8ASCN10A | |
| SCHEMBL25375109 | 0.83 | SCN8A (0.66) | LRRK2SCN8ASCN10A | |
| SCHEMBL30530156 | 0.82 | LRRK2 (0.65) | LRRK2RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023160509-A1 | AMIDINE DERIVATIVE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2023-08-31 | — | — | WO | disclosed |
| CN-116655497-A | Amidine derivative compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-08-29 | — | — | CN | disclosed |