Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Minocycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.68 |
| ▸ | USP2 | O75604 | 4/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.68 |
| ▸ | GRK6 | P43250 | 1/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | ALB | P02768 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minocycline SCHEMBL28251265 | 1.00 | TDP1 (0.68) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL28865841 | 1.00 | TDP1 (0.68) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL28280060 | 0.99 | TDP1 (0.67) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL12482265 | 0.99 | TDP1 (0.69) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL22171064 | 0.98 | TDP1 (0.70) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL18531248 | 0.98 | TDP1 (0.70) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL4960131 | 0.98 | TDP1 (0.70) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL21931671 | 0.98 | TDP1 (0.70) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL20716523 | 0.98 | TDP1 (0.70) | TDP1KDM4EUSP2HIF1APTGS1 | |
| Minocycline SCHEMBL11911315 | 0.98 | TDP1 (0.70) | TDP1KDM4EUSP2HIF1APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8992 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122079816-A | Preparation method of minocycline hydrochloride and intermediate thereof | — | 2026-05-26 | — | — | CN | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| CN-118846054-B | Application of beta-arestin-1-ser 330 site phosphorylation reagent in preparation of drugs for treating heart injury | 北京大学第三医院（北京大学第三临床医学院） | 2026-05-19 | — | — | CN | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| US-20260014384-A1 | RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS | TEPHA, INC. (US) | 2026-01-15 | — | — | US | claimed |
| US-12458733-B2 | Medical device and method for producing medical device | TERUMO KABUSHIKI KAISHA (JP) | 2025-11-04 | — | — | US | claimed |
| EP-4637789-A1 | PERIODONTAL TREATMENT METHOD AND COMPOSITION | Forward Science Technologies, LLC (US) | 2025-10-29 | — | — | EP | claimed |
| US-20250281084-A1 | COMPOSITION, COATING, AND METHOD FOR REDUCING EARLY/LATE SENSOR ATTENUATION OF ANALYTE BIOSENSOR | ABBOTT DIABETES CARE INC. | 2025-09-11 | — | — | US | claimed |
| US-5283065-A | Active spherical granules containing microcrystalline cellulose; compressible spherical granules containing mono- or di-saccharide optionally including same or different active material | AMERICAN CYANAMID COMPANY (US) | 1994-02-01 | — | — | US | claimed |
| EP-0572494-A1 | COMPOSITION FOR USE IN TRANSDERMAL ADMINISTRATION | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1993-12-08 | — | — | EP | claimed |
| WO-1993017746-A1 | ANTIBACTERIAL COATED MEDICAL IMPLANTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1993-09-16 | — | — | WO | claimed |
| CN-1075257-A | The compound method of minocycline hydrochloride capsule | HAIKOU CITY PHARMACEUTICAL FAC (CN) | 1993-08-18 | — | — | CN | claimed |
| US-5167964-A | Coating of blend of ethyl acrylate-methacrylic acid copolymer and povidone | WARNER-LAMBERT COMPANY (US) | 1992-12-01 | — | — | US | claimed |
| WO-1992014442-A1 | COMPOSITION FOR USE IN TRANSDERMAL ADMINISTRATION | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1992-09-03 | — | — | WO | claimed |
| US-5122519-A | Tetracyclines in solvent, gelling vehicle | AMERICAN CYANAMID COMPANY (US) | 1992-06-16 | — | — | US | claimed |
| EP-0410099-A1 | Stable, cosmetically acceptable topical gel formulation and method of treatment for acne | AMERICAN CYANAMID COMPANY (US) | 1991-01-30 | — | — | EP | claimed |
| CN-1048322-A | The Therapeutic Method of surface gel prescription and acne | AMERICAN CYANAMID CO (US) | 1991-01-09 | — | — | CN | claimed |
| EP-0337733-A2 | Single dose intramuscular treatment of chlamydia trachomatis infections | PFIZER INC. (US) | 1989-10-18 | — | — | EP | claimed |