Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.42 |
| ▸ | PI4KA | P42356 | 12/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 12/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.41 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30424712 | 1.00 | HDAC6 (0.42) | HDAC6PI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25213664 | 0.94 | HDAC6 (0.44) | HDAC6PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL25213667 | 0.89 | PIK3CA (0.45) | HDAC6PI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25389027 | 0.88 | PI4KA (0.39) | HDAC6PI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30425066 | 0.86 | HDAC6 (0.50) | HDAC6PI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25216541 | 0.86 | HDAC6 (0.50) | HDAC6PI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL30424980 | 0.82 | HDAC6 (0.46) | HDAC6PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL25385354 | 0.82 | HDAC6 (0.46) | HDAC6PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL25214466 | 0.82 | HDAC6 (0.45) | HDAC6PI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL25240955 | 0.82 | PIK3CA (0.64) | HDAC6PI4KAPI4KBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286970-A1 | NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-09-14 | — | — | US | claimed |
| US-20230286970-A1 | NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-09-14 | — | — | US | disclosed |
| US-20230286970-A1 | NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-09-14 | — | — | US | disclosed |
| US-20230286970-A1 | NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS | ITALFARMACO SPA (IT) | 2023-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286970-A1 | NOVEL OXADIAZOLE-BASED SELECTIVE HDAC6 INHIBITORS | HDAC6, HDAC1, HDAC3 | HDAC6 1/4885PI4KA 1295/4885PI4KB 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.