SCHEMBL25396708

SCHEMBL25396708

COCCc1nc2c(N)nc3cc(-c4cccc(CS(N)(=O)=O)c4)ccc3c2n1CC(C)(C)O

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.53
TLR8 Q9NR97 9/20 0.53
NUDT1 P36639 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29507707 1.00 TLR7 (0.53) TLR7TLR8NUDT1
SCHEMBL3865022 0.90 TLR7 (0.56) TLR7TLR8NUDT1
SCHEMBL3861955 0.87 TLR7 (0.61) TLR7TLR8NUDT1
Methane SCHEMBL3862512 0.87 TLR7 (0.53) TLR7TLR8NUDT1
SCHEMBL4552462 0.86 TLR7 (0.54) TLR7TLR8NUDT1
SCHEMBL25396713 0.84 TLR7 (0.47) TLR7TLR8NUDT1
SCHEMBL3870527 0.83 TLR7 (0.56) TLR7TLR8NUDT1
SCHEMBL3863927 0.82 TLR7 (0.54) TLR7TLR8NUDT1
SCHEMBL29373790 0.82 TLR7 (0.54) TLR7TLR8NUDT1
SCHEMBL3865783 0.81 TLR7 (0.56) TLR7TLR8NUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11702476-B2 Anti-EGFR combinations for treating tumors BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2023-07-18 US claimed
US-20220089749-A1 ANTI-EGFR COMBINATIONS FOR TREATING TUMORS BIRDIE BIOPHARMACEUTICALS, INC. (KY) 2022-03-24 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11702476-B2 Anti-EGFR combinations for treating tumors EGFR, ERBB3, ERBB2 TLR7 2007/4885TLR8 1153/4885NUDT1 3504/4885
US-20220089749-A1 ANTI-EGFR COMBINATIONS FOR TREATING TUMORS EGFR, ERBB3, ERBB2 TLR7 2007/4885TLR8 1153/4885NUDT1 3504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.