Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 17/20 | 0.77 |
| ▸ | EGFR | P00533 | 11/20 | 0.77 |
| ▸ | SRC | P12931 | 11/20 | 0.77 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.77 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.77 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.77 |
| ▸ | WEE1 | P30291 | 1/20 | 0.67 |
| ▸ | ABL1 | P00519 | 7/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.65 |
| ▸ | KIT | P10721 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763098 | 0.88 | FGFR1 (0.75) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL4839269 | 0.87 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5763230 | 0.87 | FGFR1 (0.73) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5762058 | 0.85 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5761991 | 0.85 | FGFR1 (0.70) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL30618265 | 0.85 | FGFR1 (0.70) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5761783 | 0.85 | FGFR1 (0.70) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL3762584 | 0.84 | FGFR1 (0.69) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL29498171 | 0.84 | FGFR1 (0.69) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764408 | 0.83 | FGFR1 (0.67) | FGFR1EGFRSRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023177356-A2 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-09-21 | — | — | WO | disclosed |