Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368525 | 1.00 | JAK3 (0.49) | JAK3JAK2JAK1TYK2SYK | |
| SCHEMBL1368531 | 1.00 | JAK3 (0.49) | JAK3JAK2JAK1TYK2SYK | |
| SCHEMBL1368703 | 1.00 | JAK3 (0.49) | JAK3JAK2JAK1TYK2SYK | |
| SCHEMBL25396432 | 1.00 | JAK3 (0.49) | JAK3JAK2JAK1TYK2SYK | |
| Hydrochloric Acid SCHEMBL1367825 | 0.99 | JAK3 (0.49) | JAK3JAK2JAK1TYK2SYK | |
| Hydrochloric Acid SCHEMBL1368941 | 0.99 | JAK3 (0.49) | JAK3JAK2JAK1TYK2SYK | |
| Hydrochloric Acid SCHEMBL1367827 | 0.99 | JAK3 (0.49) | JAK3JAK2JAK1TYK2SYK | |
| Fumaric Acid SCHEMBL1368558 | 0.96 | JAK3 (0.46) | JAK3JAK2JAK1TYK2SYK | |
| Fumaric Acid SCHEMBL1368560 | 0.96 | JAK3 (0.46) | JAK3JAK2JAK1TYK2SYK | |
| Maleic Acid SCHEMBL1368553 | 0.96 | JAK3 (0.46) | JAK3JAK2JAK1TYK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |