SCHEMBL2539932

SCHEMBL2539932

Cc1sc2c(c1C)C(c1ccc(-c3cccc(C#N)c3)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2

nearest known ligand 0.84

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 0.84
BRDT Q58F21 10/20 0.72
DNER Q8NFT8 1/20 0.60
BRD2 P25440 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3205819 0.92 BRD4 (0.83) BRD4BRDTDNERBRD2
SCHEMBL3215449 0.92 BRD4 (0.71) BRD4BRDTDNERBRD2
SCHEMBL3214233 0.92 BRD4 (0.71) BRD4BRDTBRD2
SCHEMBL3196656 0.92 BRD4 (0.71) BRD4BRDTBRD2
SCHEMBL17839803 0.91 BRD4 (0.85) BRD4BRDTDNERBRD2
SCHEMBL13028865 0.91 BRD4 (1.00) BRD4BRDTBRD2
SCHEMBL3211359 0.91 BRD4 (0.70) BRD4BRDT
SCHEMBL3201388 0.91 BRD4 (0.70) BRD4BRDTDNERBRD2
SCHEMBL3204942 0.90 BRD4 (0.70) BRD4BRDTDNERBRD2
SCHEMBL3197992 0.90 BRD4 (0.84) BRD4BRDTBRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1887008-B1 THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF MITSUBISHI TANABE PHARMA CORP (JP) 2021-04-21 EP claimed
EP-2863923-B1 THIENOTRIAZOLODIAZEPINE COMPOUNDS FOR THE TREATMENT OF LYMPHOMAS ONCOETHIX GMBH (CH) 2019-05-08 EP claimed
EP-3185871-A1 METHODS OF TREATING ACUTE MYELOID LEUKEMIA OR ACUTE LYMPHOID LEUKEMIA USING PHARMACEUTICAL COMPOSITIONS CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS Oncoethix GmbH (CH) 2017-07-05 EP claimed
US-20170157141-A1 METHOD OF TREATING LEUKEMIA USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX GMBH (CH) 2017-06-08 US claimed
EP-3154549-A1 METHOD OF TREATING NON-SMALL CELL LUNG CANCER AND/OR SMALL CELL LUNG CANCER USING THIENOTRIAZOLODIAZEPINE COMPOUNDS Oncoethix GmbH (CH) 2017-04-19 EP claimed
EP-3137085-A1 METHOD OF TREATING ACUTE MYELOID LEUKEMIA AND/OR ACUTE LYMPHOBLASTIC LEUKEMIA USING THIENOTRIAZOLODIAZEPINE COMPOUNDS Oncoethix GmbH (CH) 2017-03-08 EP claimed
US-20160375032-A1 METHOD OF TREATING NON-SMALL-CELL LUNG CANCER USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX GMBH (CH) 2016-12-29 US claimed
EP-3074019-A1 METHOD OF TREATING NON-SMALL-CELL LUNG CANCER USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS Oncoethix GmbH (CH) 2016-10-05 EP claimed
EP-3074018-A1 METHOD OF TREATING LEUKEMIA USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS Oncoethix GmbH (CH) 2016-10-05 EP claimed
US-20160158246-A1 METHOD OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) USING A BET-BROMODOMAIN INHIBITOR ONCOETHIX GMBH (CH) 2016-06-09 US claimed
WO-2015078928-A1 METHOD OF TREATING NON-SMALL-CELL LUNG CANCER USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX SA (CH) 2015-06-04 WO claimed
EP-2863923-A1 METHOD OF TREATING LYMPHOMA USING THIENOTRIAZOLODIAZEPINE COMPOUNDS Oncoethix SA (CH) 2015-04-29 EP claimed
WO-2015018520-A1 A BET-BRD INHIBITOR REPRESENTS A NOVEL AGENT FOR ALK POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA ONCOETHIX SA (CH) 2015-02-12 WO claimed
US-20140107107-A1 PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX GMBH (CH) 2014-04-17 US claimed
WO-2014001356-A1 METHOD OF TREATING LYMPHOMA USING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX SA (CH) 2014-01-03 WO claimed
US-8476260-B2 Antitumor agent MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-07-02 US claimed
US-20100286127-A1 ANTITUMOR AGENT MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-11-11 US claimed
EP-2239264-A1 ANTITUMOR AGENT Mitsubishi Tanabe Pharma Corporation (JP) 2010-10-13 EP claimed
US-20100041643-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-02-18 US claimed
EP-1887008-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2008-02-13 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160158246-A1 METHOD OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) USING A BET-BROMODOMAIN INHIBITOR BRD4, BRD7, BCL6 BRD4 1/4885BRDT 14/4885DNER 1306/4885
US-20170157141-A1 METHOD OF TREATING LEUKEMIA USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS CCR10, HRH4, H1-10 BRD4 22/4885BRDT 499/4885DNER 4327/4885
US-20140107107-A1 PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS HRH4, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HTR3D BRD4 97/4885BRDT 1044/4885DNER 4847/4885
US-20100286127-A1 ANTITUMOR AGENT BRDT, HDAC1, BRPF3 BRD4 4/4885BRDT 1/4885DNER 3822/4885
US-20160375032-A1 METHOD OF TREATING NON-SMALL-CELL LUNG CANCER USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HRH4, CCR10 BRD4 20/4885BRDT 198/4885DNER 2991/4885
US-20100041643-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF ICOS, CD4, CD2 BRD4 265/4885BRDT 159/4885DNER 3109/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.