Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25402636 | 0.90 | KDM4E (0.63) | KDM4EHSD17B10ALDH1A1POLBGFER | |
| SCHEMBL31083821 | 0.86 | KDM4E (0.58) | KDM4EHSD17B10ALDH1A1POLBGFER | |
| SCHEMBL25405760 | 0.85 | KMT2A (0.65) | KDM4EALDH1A1POLBPKMNAMPT | |
| SCHEMBL25402907 | 0.83 | MAPT (0.64) | ALDH1A1POLBPKMNAMPTKMT2A | |
| SCHEMBL25404953 | 0.83 | KDM4E (0.63) | KDM4ETRPV1HSD17B10ALDH1A1NAMPT | |
| SCHEMBL25403958 | 0.80 | KDM4E (0.61) | KDM4EHSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL25406299 | 0.79 | KMT2A (0.66) | KDM4EHSD17B10ALDH1A1POLBNAMPT | |
| SCHEMBL25406363 | 0.77 | POLB (0.53) | KDM4EHSD17B10ALDH1A1POLBGFER | |
| SCHEMBL31083799 | 0.77 | GLA (0.55) | KDM4EHSD17B10ALDH1A1POLBGFER | |
| SCHEMBL25405808 | 0.77 | GLA (0.55) | KDM4EHSD17B10ALDH1A1POLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118742543-A | Dihydro isoquinoline compound and medical application thereof | 中国科学院上海药物研究所 | 2024-10-01 | — | — | CN | disclosed |
| WO-2023174383-A1 | DIHYDROISOQUINOLINE COMPOUND AND MEDICAL USE THEREOF | 中国科学院上海药物研究所 | 2023-09-21 | — | — | WO | disclosed |