Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155829 | 0.92 | GRM5 (1.00) | GRM5 | |
| SCHEMBL173593 | 0.89 | GRM5 (0.85) | GRM5 | |
| SCHEMBL173765 | 0.89 | GRM5 (0.85) | GRM5 | |
| SCHEMBL159240 | 0.89 | GRM5 (0.90) | GRM5 | |
| SCHEMBL255144 | 0.88 | GRM5 (0.82) | GRM5 | |
| SCHEMBL159776 | 0.88 | GRM5 (1.00) | GRM5 | |
| SCHEMBL15293372 | 0.87 | GRM5 (0.81) | GRM5 | |
| SCHEMBL170711 | 0.87 | GRM5 (0.81) | GRM5 | |
| SCHEMBL158791 | 0.86 | GRM5 (1.00) | GRM5 | |
| SCHEMBL253711 | 0.86 | GRM5 (0.74) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012031024-A1 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2012-03-08 | — | — | WO | disclosed |