Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31300257 | 0.72 | HDAC3 (0.43) | POLBKMT2ATDP1KDM4EALDH1A1 | |
| Lysine SCHEMBL28214073 | 0.70 | GSR (0.91) | GSRDPP8DPP9DPP7POLB | |
| Lysine SCHEMBL11145520 | 0.68 | GSR (0.71) | GSRDPP8DPP9DPP7POLB | |
| Lysine SCHEMBL11145516 | 0.68 | GSR (0.71) | GSRDPP8DPP9DPP7POLB | |
| Lysine SCHEMBL1066666 | 0.68 | GSR (0.71) | GSRDPP8DPP9DPP7POLB | |
| Lysine SCHEMBL1066668 | 0.68 | GSR (0.71) | GSRDPP8DPP9DPP7POLB | |
| Lysine SCHEMBL21635386 | 0.68 | GSR (0.61) | GSRDPP8DPP9DPP7ITGB3 | |
| Lysine SCHEMBL20362357 | 0.67 | GSR (1.00) | GSRKMT2ANOS1SLC1A3SLC1A2 | |
| Lysine SCHEMBL12867528 | 0.67 | GSR (1.00) | GSRKMT2ANOS1SLC1A3SLC1A2 | |
| Lysine SCHEMBL8613373 | 0.67 | GSR (1.00) | GSRKMT2ANOS1SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178107-A2 | ORTHOGONALLY CROSSLINKED PROTEINS, METHODS OF MAKING, AND USES THEREOF | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-09-21 | — | — | WO | disclosed |