Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 4/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25421165 | 0.82 | KDM4E (0.53) | KDM4EHSD17B10KMT2APIM1PIM2 | |
| SCHEMBL23458576 | 0.77 | KDM4E (0.67) | KDM4EHSD17B10KMT2APIM1PIM2 | |
| SCHEMBL18606919 | 0.76 | MIF (0.58) | MAPK8ADORA3CDK2DYRK1A | |
| SCHEMBL6219388 | 0.75 | KDM4E (0.73) | KDM4EHSD17B10KMT2APIM1ALDH1A1 | |
| SCHEMBL30498956 | 0.74 | KDM4E (0.58) | KDM4EHSD17B10KMT2APIM1PIM2 | |
| SCHEMBL22322737 | 0.73 | KDM4E (0.57) | KDM4EHSD17B10KMT2APIM1PIM2 | |
| SCHEMBL25419836 | 0.73 | KDM4E (0.53) | KDM4EHSD17B10KMT2APIM1PIM2 | |
| SCHEMBL30396864 | 0.73 | KDM4E (0.53) | KDM4EHSD17B10KMT2APIM1PIM2 | |
| SCHEMBL16796056 | 0.72 | KDM4E (0.54) | KDM4EHSD17B10KMT2APIM1PIM2 | |
| SCHEMBL15300436 | 0.70 | PIM1 (0.69) | PIM1PIM2MAPK8MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |