Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26631452 | 0.82 | ADORA2A (0.37) | ALDH1A1KDM4EKMT2AADORA1ADORA2A | |
| SCHEMBL31365785 | 0.79 | CCNT1 (0.43) | ALDH1A1KDM4EADORA1ADORA2APRMT5 | |
| SCHEMBL21268783 | 0.79 | CCNT1 (0.43) | ALDH1A1KDM4EADORA1ADORA2APRMT5 | |
| SCHEMBL11590712 | 0.73 | AR (0.55) | ALDH1A1KDM4EKMT2AADORA1ADORA2A | |
| SCHEMBL423854 | 0.69 | AXL (0.55) | KMT2ADYRK1AGSK3BCCNT1CCNA2 | |
| SCHEMBL3827956 | 0.68 | LRRK2 (0.53) | CA5ADYRK1ACCNT1CDK9 | |
| SCHEMBL1772292 | 0.67 | PRMT5 (0.45) | PRMT5WDR77ULK1GSK3BCCNT1 | |
| SCHEMBL25935813 | 0.67 | CACNA1H (0.44) | — | |
| SCHEMBL22264317 | 0.66 | RPS6KA5 (0.42) | ALDH1A1KMT2APRMT5WDR77 | |
| SCHEMBL2577669 | 0.66 | AR (0.58) | ALDH1A1KDM4EKMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444721-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107722-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |