Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 4/20 | 0.38 |
| ▸ | PDE5A | O76074 | 7/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30422594 | 0.91 | AAK1 (0.39) | PTPN11MAPTBRAFPDE5APOLB | |
| SCHEMBL25421906 | 0.91 | PTPN11 (0.41) | PTPN11MAPTBRAFPOLB | |
| SCHEMBL25421896 | 0.91 | PTPN11 (0.41) | PTPN11MAPTBRAFPOLB | |
| SCHEMBL25419895 | 0.86 | PTPN11 (0.43) | PTPN11MAPTPOLB | |
| SCHEMBL25420441 | 0.86 | PTPN11 (0.43) | PTPN11MAPTPOLB | |
| SCHEMBL25436731 | 0.86 | PTPN11 (0.43) | PTPN11MAPTPOLB | |
| SCHEMBL25419881 | 0.86 | PTPN11 (0.43) | PTPN11MAPTPOLB | |
| Formic Acid SCHEMBL31148381 | 0.85 | PTPN11 (0.39) | PTPN11MAPTPDE5APOLBLMNA | |
| SCHEMBL31148460 | 0.84 | PTPN11 (0.41) | PTPN11MAPTBRAFPOLB | |
| SCHEMBL31148415 | 0.84 | PTPN11 (0.41) | PTPN11MAPTBRAFPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102231-A1 | 5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND METHODS OF USING THE SAME | RGENTA THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | WO | disclosed |