Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.57 |
| ▸ | CDK9 | P50750 | 7/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.57 |
| ▸ | CDK2 | P24941 | 7/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.57 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 6/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.34 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31472565 | 1.00 | CDK5 (0.57) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| SCHEMBL31499103 | 0.81 | CCNT1 (0.55) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| SCHEMBL1044715 | 0.81 | CCNT1 (0.55) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| SCHEMBL2994099 | 0.77 | CCNT1 (0.53) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| SCHEMBL16932962 | 0.77 | CCNT1 (0.56) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| SCHEMBL14837368 | 0.77 | JAK2 (0.44) | MAP3K7TAB1JAK2MAPK1DYRK1A | |
| SCHEMBL25644357 | 0.75 | CCNT1 (0.51) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| SCHEMBL2998522 | 0.74 | CCNT1 (0.73) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| SCHEMBL29941422 | 0.74 | CCNT1 (0.73) | CDK5CCNT1CDK9CDK5R1CDK2 | |
| Meriolin 5 SCHEMBL2997013 | 0.73 | CDK5 (1.00) | CDK5CCNT1CDK9CDK5R1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4444721-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107722-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |