Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.39 |
| ▸ | KIF11 | P52732 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25425516 | 0.94 | PDE5A (0.41) | PDE5AKIF11MAPTTP53SMN1; SMN2 | |
| SCHEMBL25422445 | 0.90 | PDE5A (0.41) | PDE5AKIF11MAPTTP53SMN1; SMN2 | |
| SCHEMBL25424446 | 0.89 | PDE5A (0.41) | PDE5AKIF11MAPTTP53SMN1; SMN2 | |
| SCHEMBL25427029 | 0.86 | PDE5A (0.35) | PDE5AKIF11MAPTTP53SMN1; SMN2 | |
| SCHEMBL25424049 | 0.86 | PDE5A (0.45) | PDE5AMAPTTP53SMN1; SMN2ABCB1 | |
| SCHEMBL25422984 | 0.85 | PDE5A (0.44) | PDE5AKIF11MAPTTP53SMN1; SMN2 | |
| SCHEMBL25424597 | 0.85 | PDE5A (0.49) | PDE5AKIF11TP53ABCG2NPSR1 | |
| SCHEMBL25426941 | 0.85 | PDE5A (0.51) | PDE5AKIF11MAPTTP53SMN1; SMN2 | |
| SCHEMBL25422407 | 0.84 | PDE5A (0.48) | PDE5AKIF11ABCB1ABCG2 | |
| SCHEMBL25425283 | 0.84 | PDE5A (0.42) | PDE5AKIF11MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130070-A2 | CARBOLINE COMPOUNDS AND USE THEREOF | PTC THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | claimed |