Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25428181 | 1.00 | PCSK9 (0.38) | PCSK9SYKSERPINE1AAK1MEN1 | |
| SCHEMBL26025544 | 0.92 | SERPINE1 (0.37) | PCSK9SYKSERPINE1AAK1MEN1 | |
| SCHEMBL25436831 | 0.87 | AAK1 (0.39) | PCSK9SYKSERPINE1AAK1MEN1 | |
| SCHEMBL30519641 | 0.87 | AAK1 (0.39) | PCSK9SYKSERPINE1AAK1MEN1 | |
| SCHEMBL26025543 | 0.84 | SERPINE1 (0.38) | PCSK9SYKSERPINE1AAK1CPB2 | |
| SCHEMBL17334271 | 0.82 | SYK (0.41) | PCSK9SYKCPB2GFERHSD17B10 | |
| SCHEMBL17334270 | 0.82 | SYK (0.41) | PCSK9SYKCPB2GFERHSD17B10 | |
| SCHEMBL30685725 | 0.81 | ABCB1 (0.41) | PCSK9SYKSERPINE1AAK1GAA | |
| SCHEMBL25272135 | 0.80 | HDAC6 (0.46) | MKNK2CTSSCTSK | |
| SCHEMBL25272136 | 0.80 | HDAC6 (0.46) | MKNK2CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023154282-A1 | COMPOUNDS HAVING A T-STRUCTURE FORMED BY AT LEAST FOUR CYCLES FOR USE IN THE TREATMENT OF CANCER AND OTHER INDICATIONS | THERAS, INC. (US) | 2023-08-17 | — | — | WO | disclosed |