Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30380944 | 1.00 | MAPT (0.45) | MAPTESR2NR1H2ACACBMAPK1 | |
| SCHEMBL2487129 | 0.80 | MAPT (0.46) | MAPTESR2NR1H2ACACBMAPK1 | |
| SCHEMBL30381411 | 0.78 | JAK1 (0.48) | MAPTESR2NR1H2ACACBMAPK1 | |
| SCHEMBL25307616 | 0.78 | JAK1 (0.48) | MAPTESR2NR1H2ACACBMAPK1 | |
| SCHEMBL2486452 | 0.77 | NR1H2 (0.51) | MAPTESR2NR1H2ACACBMAPK1 | |
| SCHEMBL21593127 | 0.75 | MAPT (0.44) | MAPTESR2NR1H2ACACBMAPK1 | |
| SCHEMBL2487772 | 0.75 | CKS1B (0.46) | MAPTESR2NR1H2MAPK1SCN9A | |
| SCHEMBL15779488 | 0.75 | PAK1 (0.53) | MAPTESR2NR1H2 | |
| SCHEMBL15778873 | 0.75 | NR1H2 (0.51) | MAPTESR2NR1H2 | |
| SCHEMBL21593128 | 0.75 | NR1H2 (0.53) | MAPTESR2NR1H2ACACBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107723-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |