Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 9/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2543207 | 1.00 | BRD4 (0.38) | BRD4BRDTBRD2POLQCD274 | |
| SCHEMBL3210293 | 0.86 | BRD4 (0.47) | BRD4BRDTBRD2 | |
| SCHEMBL2540727 | 0.83 | BRD4 (0.52) | BRD4BRDT | |
| SCHEMBL2539794 | 0.78 | BRD4 (0.56) | BRD4BRDT | |
| SCHEMBL2539800 | 0.78 | BRD4 (0.56) | BRD4BRDT | |
| SCHEMBL2536621 | 0.76 | BRD4 (0.49) | BRD4BRDTBRD2 | |
| SCHEMBL2536623 | 0.76 | BRD4 (0.49) | BRD4BRDTBRD2 | |
| SCHEMBL2542061 | 0.71 | BRD4 (0.68) | BRD4BRDT | |
| SCHEMBL2540750 | 0.71 | BRD4 (0.58) | BRD4BRDT | |
| SCHEMBL2534246 | 0.70 | BRD4 (0.57) | BRD4BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044042-B2 | Thienotriazolodiazepine compound and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-10-25 | — | — | US | disclosed |