SCHEMBL25439272

SCHEMBL25439272

COc1ccc(-c2noc(N3CCC(C(=O)NC[C@@H]4CCN(C[C@H]5CCCN(C(=O)O)C5)C4)CC3)n2)cc1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.56
▸ KMT2A Q03164 5/20 0.56
▸ LMNA P02545 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.52
▸ MAPT P10636 1/20 0.50
▸ RAB9A P51151 1/20 0.48
▸ POLB P06746 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25439275 1.00 MEN1 (0.56) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL30584822 0.92 MEN1 (0.60) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL31667442 0.92 MEN1 (0.60) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL31667729 0.92 MEN1 (0.60) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL31667455 0.92 MEN1 (0.60) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL31546454 0.92 MEN1 (0.61) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL31546409 0.92 MEN1 (0.61) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL30584978 0.92 MEN1 (0.54) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL30584852 0.92 MEN1 (0.54) MEN1KMT2ALMNASMN1; SMN2MAPT
SCHEMBL30584709 0.92 MEN1 (0.54) MEN1KMT2ALMNASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023177700-A2 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2023-09-21 — — WO disclosed
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