Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 6/20 | 0.46 |
| ▸ | BRD2 | P25440 | 3/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2538693 | 1.00 | BRD4 (0.53) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL2543539 | 0.92 | BRD4 (0.55) | BRD4BRDT | |
| SCHEMBL2535916 | 0.89 | BRD4 (0.64) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL2535423 | 0.89 | BRD4 (0.64) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL2541368 | 0.87 | BRD4 (0.60) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL2541366 | 0.87 | BRD4 (0.60) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL3198363 | 0.87 | BRD4 (0.65) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL2537230 | 0.86 | BRD4 (0.61) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL2537226 | 0.86 | BRD4 (0.61) | BRD4BRDTBRD2BRD3ADORA3 | |
| SCHEMBL2542766 | 0.86 | BRD4 (0.50) | BRD4BRDTBRD2ADORA3TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044042-B2 | Thienotriazolodiazepine compound and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-10-25 | — | — | US | disclosed |