Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | BMP1 | P13497 | 1/20 | 0.41 |
| ▸ | MDM4 | O15151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26970068 | 1.00 | KMT2A (0.50) | KMT2AEPHX2CASP3BMP1MDM4 | |
| SCHEMBL17106632 | 1.00 | KMT2A (0.50) | KMT2AEPHX2CASP3BMP1MDM4 | |
| Hydrochloric Acid SCHEMBL25171597 | 0.99 | KMT2A (0.49) | KMT2AEPHX2CASP3BMP1MDM4 | |
| Hydrochloric Acid SCHEMBL25171596 | 0.99 | KMT2A (0.49) | KMT2AEPHX2CASP3BMP1MDM4 | |
| SCHEMBL5631609 | 0.88 | KMT2A (0.54) | KMT2AEPHX2CASP3BMP1 | |
| SCHEMBL5629775 | 0.88 | KMT2A (0.54) | KMT2AEPHX2CASP3BMP1 | |
| Hydrochloric Acid SCHEMBL29902249 | 0.88 | KMT2A (0.52) | KMT2AEPHX2CASP3MDM2 | |
| Hydrochloric Acid SCHEMBL5629771 | 0.87 | KMT2A (0.53) | KMT2AEPHX2CASP3BMP1 | |
| Hydrochloric Acid SCHEMBL5629777 | 0.87 | KMT2A (0.53) | KMT2AEPHX2CASP3BMP1 | |
| SCHEMBL16623132 | 0.87 | KMT2A (0.55) | KMT2AEPHX2CASP3BMP1MDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME LLC | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230144324-A1 | PCSK9 ANTAGONIST COMPOUNDS | PCSK9, PCSK7, PCSK6 | KMT2A 1269/4885EPHX2 1990/4885CASP3 2101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.