Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.56 |
| ▸ | INSR | P06213 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | NPM1 | P06748 | 9/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521216 | 0.92 | JAK2 (0.67) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL2544751 | 0.88 | JAK2 (0.59) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL520100 | 0.79 | JAK2 (0.64) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL521083 | 0.76 | JAK2 (0.69) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL521627 | 0.75 | JAK2 (0.61) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL520390 | 0.74 | JAK2 (0.70) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL521070 | 0.74 | JAK2 (0.62) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL520357 | 0.74 | JAK2 (0.71) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL521939 | 0.74 | JAK2 (1.00) | JAK2ALKINSRCYP3A4PTK2 | |
| SCHEMBL520910 | 0.73 | JAK2 (0.59) | JAK2ALKINSRCYP3A4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |