Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25457843 | 0.97 | HRH3 (0.36) | KDM4EHRH3HTTATMMETAP1 | |
| SCHEMBL25452836 | 0.93 | METAP1 (0.38) | HRH3METAP1AKR1B1CA1CA2 | |
| SCHEMBL29813861 | 0.83 | MEN1 (0.39) | HRH3METAP1AKR1B1CA1CA2 | |
| SCHEMBL26143928 | 0.83 | METAP1 (0.35) | KDM4EMETAP1AKR1B1CA1CA2 | |
| SCHEMBL20672175 | 0.80 | METAP1 (0.38) | KDM4EHRH3HTTATMMETAP1 | |
| SCHEMBL25174304 | 0.79 | MEN1 (0.39) | HRH3METAP1AKR1B1CA1CA2 | |
| SCHEMBL30372231 | 0.79 | MEN1 (0.39) | HRH3METAP1AKR1B1CA1CA2 | |
| SCHEMBL30620824 | 0.78 | HRH3 (0.52) | KDM4EHRH3KMT2AOPRM1POLB | |
| SCHEMBL27445311 | 0.77 | HPGD (0.40) | HRH3MAOAMAOBKMT2AOPRM1 | |
| SCHEMBL12549140 | 0.76 | CA1 (0.39) | KDM4EHTTMETAP1AKR1B1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081845-A1 | AKT3 MODULATORS | GEORGIAMUNE LLC (US) | 2023-05-11 | — | — | WO | disclosed |