Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 20/20 | 0.44 |
| ▸ | DNER | Q8NFT8 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.39 |
| ▸ | BRD2 | P25440 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534315 | 0.90 | BRD4 (0.52) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL2543043 | 0.88 | BRD4 (0.58) | BRD4DNERBRDT | |
| SCHEMBL2543487 | 0.86 | BRD4 (0.51) | BRD4DNERBRDT | |
| SCHEMBL3211715 | 0.86 | BRD4 (0.59) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL2545756 | 0.85 | BRD4 (0.50) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL2537131 | 0.83 | BRD4 (0.52) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL2542552 | 0.83 | BRD4 (0.53) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL2541446 | 0.83 | BRD4 (0.52) | BRD4DNERBRDTBRD2ADORA3 | |
| SCHEMBL2541274 | 0.81 | BRD4 (0.51) | BRD4DNERBRDT | |
| SCHEMBL2540559 | 0.81 | BRD4 (0.46) | BRD4BRDTADORA3TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044042-B2 | Thienotriazolodiazepine compound and medicinal use thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-10-25 | — | — | US | disclosed |