SCHEMBL25465760

SCHEMBL25465760

CC(=O)c1ccc2nc(CN3CCC(c4cccc(CC(O)c5ccc(C#N)cc5)n4)CC3)n(Cc3cncs3)c2c1

nearest known ligand 0.47

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 20/20 0.47
▸ HTR1A P08908 1/20 0.43
▸ CYP2C8 P10632 1/20 0.43
▸ KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25121202 0.94 GLP1R (0.54) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL25121129 0.93 GLP1R (0.47) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL25465761 0.90 GLP1R (0.49) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL25121124 0.85 GLP1R (0.57) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL25121128 0.83 GLP1R (0.49) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL25465763 0.81 GLP1R (0.49) GLP1R
SCHEMBL25465659 0.80 GLP1R (0.73) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL25121331 0.78 GLP1R (0.58) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL31120408 0.74 GLP1R (0.80) GLP1RHTR1ACYP2C8KCNH2
SCHEMBL25121200 0.74 GLP1R (0.47) GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230150998-A1 COMPOUNDS AS GLP-1R AGONISTS Terns, Inc. 2023-05-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150998-A1 COMPOUNDS AS GLP-1R AGONISTS GLP1R, GIPR, GCGR GLP1R 1/4885HTR1A 246/4885CYP2C8 2376/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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