SCHEMBL254689

SCHEMBL254689

N#Cc1ncc(N)cn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3673998 0.74 KDM4E (0.54)
SCHEMBL765184 0.72
SCHEMBL18914327 0.72
SCHEMBL20886067 0.72
SCHEMBL217344 0.72
SCHEMBL3456377 0.72
SCHEMBL236034 0.72
SCHEMBL2140092 0.72
SCHEMBL17768549 0.72 KDM4E (0.35)
SCHEMBL14872282 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113717382-B Porphyrin and pyrimidine based high-density metallized covalent triazine polymer and preparation method and application thereof 浙江工业大学 2022-08-19 CN claimed
CN-113717382-A Porphyrin and pyrimidine-based high-density metallized covalent triazine polymer and preparation method and application thereof 浙江工业大学 2021-11-30 CN claimed
CN-106866699-A A kind of RTIs of diaryl thienopyrimidines HIV 1 and its preparation method and application 山东大学 2017-06-20 CN claimed
EP-2507243-B1 SPIROINDOLINONE PYRROLIDINES HOFFMANN LA ROCHE (CH) 2015-06-10 EP claimed
CN-102276537-B Preparation method of 2-cyan-5-amiopyrimidine UNIV SHANXI 2013-01-23 CN claimed
EP-2507243-A1 SPIROINDOLINONE PYRROLIDINES F. Hoffmann-La Roche AG (CH) 2012-10-10 EP claimed
US-20260090270-A1 ORGANIC ELECTRONIC ELEMENT AND COMPOUND TOSOH CORPORATION (JP) 2026-03-26 US disclosed
EP-4334298-B1 UREA DERIVATIVES WHICH CAN BE USED TO TREAT CANCER SCORPION THERAPEUTICS INC (US) 2026-02-18 EP disclosed
EP-4638445-A1 1,2,4-THIAZOLIDIN-3-ONE-1,1-DIOXIDE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE Bristol-Myers Squibb Company (US) 2025-10-29 EP disclosed
EP-4626191-A1 ORGANIC ELECTRONIC ELEMENT AND COMPOUND Tosoh Corporation (JP) 2025-10-01 EP disclosed
US-20250250259-A1 METHODS FOR TREATING CANCER SCORPION THERAPEUTICS, INC. 2025-08-07 US disclosed
CN-120167151-A Organic electronic component and compound 东曹株式会社 2025-06-17 CN disclosed
US-12312341-B2 Methods for treating cancer SCORPION THERAPEUTICS, INC. (US) 2025-05-27 US disclosed
WO-2011067185-A1 SPIROINDOLINONE PYRROLIDINES F. HOFFMANN-LA ROCHE AG (CH) 2011-06-09 WO disclosed
US-20110130398-A1 SPIROINDOLINONE PYRROLIDINES BARTKOVITZ DAVID JOSEPH 2011-06-02 US disclosed
US-7235559-B1 Therapeutic quinazoline derivatives ASTRAZENECA AB (SE) 2007-06-26 US disclosed
EP-1218355-A1 THERAPEUTIC QUINAZOLINE DERIVATIVES AstraZeneca AB (SE) 2002-07-03 EP disclosed
WO-2001021597-A1 THERAPEUTIC QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2001-03-29 WO disclosed
US-4997667-A Pyridinyl compounds of N-carbamoyl-N-thiocarbamoyl- or N-amidino-glycine or beta-alanine useful as sweetening agents UNIVERSITE CLAUDE BERNARD (FR) 1991-03-05 US disclosed
EP-0321369-A1 Heterocyclic sweeteners derived from N-carbamoyl-, N-thiocarbamoyl or N-amidino-glycine or beta-alanine UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) 1989-06-21 EP disclosed