Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 1.00 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 1.00 |
| ▸ | CISD1 | Q9NZ45 | 5/20 | 1.00 |
| ▸ | MAOA | P21397 | 2/20 | 1.00 |
| ▸ | MAOB | P27338 | 2/20 | 1.00 |
| ▸ | PNP | P00491 | 1/20 | 0.74 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.68 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.68 |
| ▸ | TTR | P02766 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 1/20 | 0.63 |
| ▸ | IGF1R | P08069 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1249973 | 1.00 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL1249975 | 1.00 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL7562042 | 0.85 | CISD1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL7562040 | 0.85 | CISD1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL2544417 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL1250573 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL1250576 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL1250348 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL2548389 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB | |
| SCHEMBL1250346 | 0.83 | PIM1 (1.00) | PIM1PIM2CISD1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110263664-A1 | Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2011-10-27 | — | — | US | disclosed |
| EP-2217235-A2 | INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS, AND METHODS FOR TREATING CANCER | Musc Foundation for Research Development (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009064486-A9 | INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS, AND METHODS FOR TREATING CANCER | MUSC FOUND FOR RES DEV (US) | 2009-07-16 | — | — | WO | disclosed |
| WO-2009064486-A2 | INHIBITORS OF PIM PROTEIN KINASES, COMPOSITIONS, AND METHODS FOR TREATING CANCER | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263664-A1 | Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer | PIM1, PIM2, PIM3 | PIM1 1/4885PIM2 2/4885CISD1 3097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.