Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | GRN | P28799 | 2/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465670 | 0.85 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL19350918 | 0.84 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL1012925 | 0.82 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL1781542 | 0.81 | GRN (0.57) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL1010615 | 0.80 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1013221 | 0.80 | RAF1 (0.49) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL23637699 | 0.78 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1012412 | 0.77 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL4459497 | 0.76 | MAPK14 (0.50) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL1012616 | 0.74 | MAPK13 (0.66) | MAPK14MAPK13MAPK12MAPK11JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |