Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2504088 | 0.83 | AAK1 (0.53) | AAK1PRCPL3MBTL1TSHR | |
| SCHEMBL2504091 | 0.83 | AAK1 (0.53) | AAK1PRCPL3MBTL1TSHR | |
| SCHEMBL2505196 | 0.81 | AAK1 (0.48) | AAK1PRCPL3MBTL1TSHR | |
| SCHEMBL13498185 | 0.81 | AAK1 (0.48) | AAK1PRCPL3MBTL1TSHR | |
| SCHEMBL2505194 | 0.81 | AAK1 (0.48) | AAK1PRCPL3MBTL1TSHR | |
| SCHEMBL8330091 | 0.81 | TSHR (0.59) | AAK1L3MBTL1TSHR | |
| SCHEMBL6304376 | 0.81 | TSHR (0.59) | AAK1L3MBTL1TSHR | |
| SCHEMBL22078549 | 0.77 | PRCP (0.47) | AAK1PRCP | |
| SCHEMBL29915611 | 0.77 | PRCP (0.47) | AAK1PRCP | |
| SCHEMBL15116772 | 0.76 | AAK1 (0.66) | AAK1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552908-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123751-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2011-10-06 | — | — | WO | disclosed |