SCHEMBL25499296

SCHEMBL25499296

C[C@H]1CC(C)(F)CN1C(=O)CNC(=O)c1ccnc2ccc(OC(C)(C)C)cc12

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DPP9 Q86TI2 8/20 0.58
PREP P48147 6/20 0.58
DPP4 P27487 5/20 0.58
FAP Q12884 7/20 0.52
DPP8 Q6V1X1 2/20 0.52
PITRM1 Q5JRX3 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27347253 0.90 DPP9 (0.59) DPP9PREPDPP4FAPDPP8
SCHEMBL25499546 0.89 DPP9 (0.61) DPP9PREPDPP4FAPDPP8
SCHEMBL27347157 0.85 DPP9 (0.55) DPP9PREPDPP4FAPDPP8
SCHEMBL26764256 0.77 DPP9 (0.60) DPP9PREPDPP4FAPDPP8
SCHEMBL15130011 0.73 DPP9 (1.00) DPP9PREPDPP4FAPDPP8
SCHEMBL15130010 0.73 DPP9 (1.00) DPP9PREPDPP4FAPDPP8
SCHEMBL23567893 0.73 DPP9 (0.86) DPP9PREPDPP4FAPDPP8
SCHEMBL26231103 0.73 PREP (0.77) DPP9PREPDPP4FAP
SCHEMBL26839934 0.72 DPP9 (0.72) DPP9PREPDPP4FAPDPP8
SCHEMBL31505495 0.72 DPP9 (0.75) DPP9PREPDPP4FAPDPP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159495-A1 COMPOUND OR ITS SALT THEREOF TARGETING FIBROBLAST ACTIVATION PROTEIN, ITS PREPARATION METHODS AND ITS USES THEREOF INSTITUTE OF NUCLEAR ENERGY RESEARCH ATOMIC ENERGY COUNCIL, R.O.C. (TW) 2023-05-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159495-A1 COMPOUND OR ITS SALT THEREOF TARGETING FIBROBLAST ACTIVATION PROTEIN, ITS PREPARATION METHODS AND ITS USES THEREOF FIBP, FGFR2, FGFR1 DPP9 1271/4885PREP 2530/4885DPP4 3076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.