Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 19/20 | 0.95 |
| ▸ | MET | P08581 | 12/20 | 0.81 |
| ▸ | MERTK | Q12866 | 10/20 | 0.79 |
| ▸ | AURKA | O14965 | 1/20 | 0.73 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | ABL1 | P00519 | 1/20 | 0.73 |
| ▸ | EGFR | P00533 | 1/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | LYN | P07948 | 1/20 | 0.73 |
| ▸ | RET | P07949 | 1/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.73 |
| ▸ | HCK | P08631 | 1/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | KIT | P10721 | 1/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21201065 | 0.97 | AXL (1.00) | AXLMETMERTKAURKARIPK2 | |
| Zanzalintinib SCHEMBL21200856 | 0.90 | AXL (1.00) | AXLMETMERTKAURKARIPK2 | |
| Zanzalintinib SCHEMBL29378531 | 0.90 | AXL (1.00) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21200981 | 0.90 | AXL (0.81) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21200644 | 0.90 | AXL (0.81) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL22766276 | 0.90 | AXL (0.81) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21201281 | 0.90 | AXL (1.00) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21201056 | 0.88 | AXL (0.85) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21201024 | 0.88 | AXL (0.86) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21201060 | 0.88 | AXL (1.00) | AXLMETMERTKAURKARIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081253-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | EXELIXIS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |