Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 5/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069182 | 0.85 | RET (0.48) | RETGRM5NTRK1CTSACNR2 | |
| SCHEMBL20147623 | 0.83 | RET (0.46) | RETGRM5NTRK1CTSACNR2 | |
| SCHEMBL20069611 | 0.75 | RET (0.49) | RETGRM5CTSAPTPN11 | |
| SCHEMBL25504259 | 0.73 | RET (0.47) | RETGRM5CTSAPTPN11 | |
| SCHEMBL20147659 | 0.72 | RET (0.48) | RETGRM5CTSA | |
| SCHEMBL20069179 | 0.72 | RET (0.48) | RETNTRK1CNR2PTPN11 | |
| SCHEMBL20069773 | 0.70 | RET (0.44) | RETGRM5CTSAPTPN11 | |
| SCHEMBL20147620 | 0.70 | RET (0.46) | RET | |
| SCHEMBL21652054 | 0.68 | RET (0.43) | RETGRM5CTSAPTPN11 | |
| SCHEMBL20147644 | 0.68 | RET (0.42) | RETGRM5CTSAPTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2023-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | RET 1/4885GRM5 1363/4885NTRK1 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.