Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.53 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30662086 | 0.74 | KDM4E (0.59) | KDM4EHTTMAPTTDP1ALDH1A1 | |
| SCHEMBL29865427 | 0.71 | KDM4E (0.56) | KDM4EHTTMAPTTDP1ALDH1A1 | |
| SCHEMBL4049805 | 0.71 | MGAM (0.44) | KDM4EHTTMAPTTDP1ALDH1A1 | |
| SCHEMBL1650258 | 0.70 | KDM4E (0.43) | KDM4EHTTMAPTTDP1ALDH1A1 | |
| SCHEMBL10650165 | 0.68 | KDM4E (0.39) | KDM4EHTTMAPTTDP1ALDH1A1 | |
| SCHEMBL377324 | 0.68 | KDM4E (0.56) | KDM4EHTTMAPTTDP1ALDH1A1 | |
| SCHEMBL6287282 | 0.68 | PARP1 (0.46) | KDM4EMAPTALDH1A1HPGDPARP1 | |
| SCHEMBL29865416 | 0.68 | KDM4E (0.56) | KDM4EHTTMAPTTDP1ALDH1A1 | |
| SCHEMBL11277554 | 0.68 | KDM4E (0.62) | KDM4EMAPTALDH1A1HPGDLMNA | |
| SCHEMBL28026979 | 0.67 | KDM4E (0.55) | KDM4EHTTMAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123419-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-06 | — | — | WO | disclosed |