Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK1 | Q96PY6 | 9/20 | 0.51 |
| ▸ | WEE1 | P30291 | 11/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551422 | 0.89 | WEE1 (0.51) | WEE1CHEK1 | |
| SCHEMBL2574942 | 0.84 | WEE1 (0.53) | WEE1CHEK1 | |
| SCHEMBL2546633 | 0.82 | NR1I2 (0.49) | NEK1WEE1CHEK1 | |
| SCHEMBL2544993 | 0.77 | TNKS (0.47) | — | |
| SCHEMBL2564831 | 0.76 | CHEK1 (0.47) | WEE1CHEK1 | |
| Hydrochloric Acid SCHEMBL15092541 | 0.76 | TNKS (0.46) | — | |
| SCHEMBL14672729 | 0.75 | NEK1 (0.57) | NEK1WEE1CHEK1 | |
| SCHEMBL2550354 | 0.74 | CHEK1 (0.45) | WEE1CHEK1 | |
| SCHEMBL2546499 | 0.74 | PARP1 (0.40) | NEK1WEE1CHEK1 | |
| Hydrochloric Acid SCHEMBL15092457 | 0.74 | CHEK1 (0.45) | WEE1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552206-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011123419-A1 | TRYCYCLIC COMPOUNDS AND PBK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2011-10-06 | — | — | WO | disclosed |