Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25498556 | 0.86 | POLB (0.58) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL3225477 | 0.86 | MEN1 (0.57) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL13503858 | 0.85 | HPGD (0.67) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL12217821 | 0.83 | KMT2A (0.60) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL14345351 | 0.81 | KMT2A (0.77) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL2935954 | 0.81 | KMT2A (0.59) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL2377982 | 0.81 | KMT2A (0.59) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL849340 | 0.81 | HPGD (0.59) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL25498355 | 0.80 | POLB (0.71) | KMT2AMEN1HPGDTSHRPOLB | |
| SCHEMBL10724841 | 0.79 | POLB (0.81) | KMT2AMEN1HPGDTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023086399-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | NURIX THERAPEUTICS, INC. (US) | 2023-05-19 | — | — | WO | disclosed |