Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | GAK | O14976 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.33 |
| ▸ | CASP1 | P29466 | 5/20 | 0.33 |
| ▸ | CASP7 | P55210 | 5/20 | 0.33 |
| ▸ | USP2 | O75604 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2548897 | 0.92 | CCNT1 (0.37) | BRD4GAKCCNT1CDK9ALDH1A1 | |
| SCHEMBL2552283 | 0.87 | BRD4 (0.36) | BRD4CCNT1CDK9ALDH1A1HSD17B10 | |
| SCHEMBL14616820 | 0.87 | RIPK2 (0.39) | BRD4GAKALDH1A1HSD17B10KDM4E | |
| Trifluoroacetic Acid SCHEMBL14575891 | 0.86 | CCNT1 (0.37) | BRD4CCNT1CDK9ALDH1A1HSD17B10 | |
| SCHEMBL2552056 | 0.85 | RPS6KA5 (0.35) | ALDH1A1KDM4ETSHRMAP3K11PFKFB3 | |
| SCHEMBL2554752 | 0.85 | MAP3K11 (0.34) | CCNT1CDK9MAP3K11 | |
| SCHEMBL2549697 | 0.84 | MAP3K11 (0.38) | ALDH1A1HSD17B10CYP1A2CASP1CASP7 | |
| SCHEMBL2546139 | 0.84 | RPS6KA5 (0.34) | ALDH1A1KDM4ETSHRMAP3K11PFKFB3 | |
| SCHEMBL2551140 | 0.83 | TTK (0.38) | BRD4GAKCCNT1CDK9SYK | |
| SCHEMBL2551527 | 0.82 | MTOR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018039-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-17 | — | — | US | claimed |
| EP-2552208-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-02-06 | — | — | EP | disclosed |
| US-20130018039-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2013-01-17 | — | — | US | disclosed |
| WO-2011123609-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018039-A1 | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | MAP3K19, MAP3K20, MAP3K3 | BRD4 551/4885GAK 149/4885CCNT1 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.